Table 4.
The differential percentage of promoter methylation in tumor suppressor genes among mesenchymal-like ovarian cancer stromal progenitor cells from tissues, ovarian cancer tissues, and mesenchymal-like ovarian cancer stromal progenitor cells from ascites
| Gene name | MSc-OCSPC (T) (%) | OC (T) (%) | MSc-OCSPC (A) (%) | p-value |
|---|---|---|---|---|
| DLC1 | 3/11 (27%) | 3/11 (27%) | 5/11 (45%) | 0.580 |
| RASSF1A* | 2/11 (18%) | 5/11 (45%) | 5/11 (45%) | 0.308 |
| CDH13 | 0/11 (0%) | 3/11 (27%) | 1/11 (9%) | 0.137 |
| BRCA1 | 0/11 (0%) | 2/11 (18%) | 2/11 (18%) | 0.320 |
| TIMP3 | 3/11 (27%) | 0/11 (0%) | 4/11 (36%) | 0.095 |
| SCGB3A1 | 1/11 (9%) | 2/11 (18%) | 2/11 (18%) | 0.790 |
| ESR1 | 2/11 (18%) | 0/11 (0%) | 2/11 (18%) | 0.320 |
| CDKN2A | 0/11 (0%) | 3/11 (27%) | 1/11 (9%) | 0.137 |
| CCND2** | 3/11 (27%) | 6/11 (55%) | 5/11 (45%) | 0.420 |
| CDKN2B | 6/11 (55%) | 6/11 (55%) | 8/11 (73%) | 0.602 |
| RUNX3 | 1/11 (18%) | 1/11 (9%) | 1/11 (9%) | 1 |
| RARB | 3/11 (27%) | 0/11 (0%) | 0/11 (0%) | 0.037 |
| HLTF | 1/11 (9%) | 0/11 (0%) | 0/11 (0%) | 0.357 |
| SFRP4 | 0/11 (0%) | 1/11 (9%) | 0/11 (0%) | 0.357 |
| CACNA1A | 0/11 (0%) | 1/11 (9%) | 1/11 (9%) | 0.587 |
| H2AFX | 0/11 (0%) | 1/11 (9%) | 0/11 (0%) | 0.409 |
| FHIT | 0/11 (%) | 0/11(0%) | 0/11 (0%) | NA |
| ID4 | 0/11 (%) | 0/11(0%) | 0/11 (0%) | NA |
| SFRP5 | 0/11 (0%) | 1/11 (9%) | 0/11 (0%) | 0.409 |
Note: MSc-OCSPC (T): Mesenchymal-like Ovarian Cancer Stromal Progenitor Cells from Tissues; OC (T): Ovarian Cancer Tissues; MSc-OCSPC (A): Mesenchymal-like Ovarian Cancer Stromal Progenitor Cells from Ascites;
*
represents probe RASSF1A382;
**
represents probe CCND2142.