Table 5.
The significantly differential percentage of promoter methylation in tumor suppressor genes between ovarian cyst tissues and ovarian cancer tissues
| Gene name | Number of methylation/all (%) | p-value | |
|---|---|---|---|
|
| |||
| Group 1 | Group 2 | ||
| RASSF1A* | 0/60 (0%) | 44/110 (40%) | <0.001 |
| RASSF1A** | 0/60 (0%) | 47/110 (43%) | <0.001 |
| APC | 0/60 (0%) | 11/110 (10%) | 0.011 |
| CDH13 | 0/60 (0%) | 27/110 (26%) | <0.001 |
| BRCA1 | 0/60 (0%) | 11/110 (10%) | 0.011 |
| TIMP3 | 10/60 (17%) | 3/110 (3%) | 0.001 |
| SCGB3A1 | 0/60 (0%) | 10/110 (9%) | 0.016 |
| SFRP5 | 0/60 (0%) | 15/110 (14%) | 0.003 |
| CCND2# | 2/60 (3%) | 27/110 (25%) | <0.001 |
| CCND2## | 10/60 (12%) | 49/110 (45%) | <0.001 |
| CACNA1A | 0/60 (0%) | 27/110 (25%) | <0.001 |
Note: group 1: ovarian cysts tissues; group 2: ovarian cancer tissues.
*
probe 1: RASSF1A(328);
**
probe 2: RASSF1A: RASSF1A(382).
#
probe1: CCND2(220);
##
probe 2: CCND2(142).