Table 4.
Potential factors influencing antibiotic resistance of H. pylori
| Resistance rate, N (%) | AMX | CAMa | LVXb | MNZc | TCN | FUR |
|---|---|---|---|---|---|---|
| Age | ||||||
| ≤ 20 | 0 | 5 (25.0) | 2 (10.0) | 12 (60.0) | 0 | 0 |
| 21-30 | 0 | 26 (19.4) | 18 (13.4) | 105 (78.4) | 0 | 2 (1.5) |
| 31-40 | 0 | 89 (31.5) | 68 (24.0) | 216 (76.3) | 0 | 2 (0.7) |
| 41-50 | 1 | 67 (26.4) | 99 (39.0) | 216 (85.0) | 0 | 1 (0.4) |
| 51-60 | 0 | 68 (27.8) | 85 (34.7) | 198 (80.8) | 0 | 0 |
| 61-70 | 0 | 46 (32.2) | 6 (42.0) | 118 (82.5) | 1 (0.7) | 1 (0.7) |
| 71-80 | 0 | 9 (24.3) | 15 (40.5) | 27 (73.0) | 0 | 0 |
| P value | 0.758 | 0.023 | < 0.001 | 0.037 | 0.339 | 0.645 |
| Gender | ||||||
| male | 0 | 117 (22.9) | 123 (24.0) | 393 (76.7) | 1 (0.2) | 1 (0.2) |
| female | 1 (0.2) | 193 (32.0) | 224 (37.1) | 499 (82.7) | 0 | 5 (0.8) |
| P value | 1.00 | 0.001 | < 0.001 | 0.015 | 0.459 | 0.303 |
| Endoscopic diagnosis | ||||||
| Chronic gastritis | 1 (0.1) | 274 (31.3) | 291 (33.3) | 708 (80.9) | 1 (0.1) | 6 (0.7) |
| Peptic ulcer | 0 | 36 (14.9) | 56 (23.2) | 184 (76.4) | 0 | 0 |
| P value | 1.00 | < 0.001 | 0.03 | 0.117 | 1.00 | 0.429 |
AMX, amoxicillin; CAM, clarithromycin; LEV, levofloxacin; MNZ, metronidazole; TCN, tetracycline; FUR, furazolidone.
a
significant differences in clarithromycin resistance rate in relation to gender (OR 1.420, 95% CI: 1.080-1.868, P = 0.012) and endoscopic diagnosis (OR 0.415, 95% CI: 0.282-0.611, P < 0.01).
b
significant differences in levofloxacin resistance rate in relation to age (OR 1.030, 95% CI: 1.020-1.041, P < 0.01), gender (OR 1.694, 95% CI: 1.293-2.219, P < 0.01) and endoscopic diagnosis (OR 0.707, 95% CI: 0.502-0.996, P = 0.035).
c
significant differences in metronidazole resistance rate in relation to gender (OR 1.377, 95% CI: 1.021-1.857, P = 0.036).