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. 2022 Nov 24;10:1046617. doi: 10.3389/fcell.2022.1046617

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Copyright © 2022 Andrade and Echard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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– Decrease in tension at the ICB triggers ESCRT-III polymerization and successful abscission in epithelial cells. Left panel: Decrease in the ICB tension and reduction of actomyosin contractility at the Entry Points (EPs) allow ESCRT-III polymerization, as cells progress towards abscission. Top right panel: Tension results from a combination of membrane tension and actomyosin-dependent cortical tension. Box: Schematic summarizing the contribution of the actomyosin network to the ICB tension, ESCRT-III polymerization and abscission. Y27632: drug that inhibits ROCK and prevents the phosphorylation (activation) of myosin II.