Table 2.
Generalized Additive Mixed-effects Models (GAMMs) examining associations between age (up to 18-years-old) and fronto-striatal resting-state functional connectivity. Sex was modeled as covariates in main and interaction models. Post-hoc within sex tests were performed only for fronto-striatal connections exhibiting significant age-by-sex interactions.
| Age main effect |
Age*sex interaction |
Age (in males) |
Age (in females) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Striatal ROI | Frontal ROI | F-statistic | pBonferroni | F-statistic | pBonferroni | F-statistic | pBonferroni | F-statistic | pBonferroni |
| NAcc | |||||||||
| ant.vmPFC | 7.10 | 0.016 * | 1.27 | 1.00 | |||||
| sgACC | 2.95 | 0.95 | 0.97 | 1.00 | |||||
| rACC | 3.62 | 0.49 | 0.74 | 1.00 | |||||
| vACC | 4.89 | 0.14 | 0.45 | 1.00 | |||||
| dlPFC | 1.60 | 1.00 | 0.23 | 1.00 | |||||
| vlPFC | 5.46 | 0.079 | 1.97 | 1.00 | |||||
| caudate | |||||||||
| ant.vmPFC | 6.58 | 0.026 * | 7.87 | 0.007 * * | 13.35 | < .0001 * ** | 0.45 | 1.00 | |
| sgACC | 0.61 | 1.00 | 3.12 | 0.80 | |||||
| rACC | 6.65 | 0.024 * | 24.89 | < .0001 * ** | 29.41 | < .0001 * ** | 1.66 | 1.00 | |
| vACC | 0.45 | 1.00 | 11.34 | 0.0002 * ** | 7.43 | 0.004 * * | 4.32 | 0.08 | |
| dlPFC | 3.71 | 0.45 | 1.91 | 1.00 | |||||
| vlPFC | 7.14 | 0.015 * | 4.08 | 0.31 | |||||
| putamen | |||||||||
| ant.vmPFC | 0.87 | 1.00 | 0.002 | 1.00 | |||||
| sgACC | 0.97 | 1.00 | 2.49 | 1.00 | |||||
| rACC | 0.68 | 1.00 | 1.64 | 1.00 | |||||
| vACC | 0.45 | 0.50 | 0.25 | 1.00 | |||||
| dlPFC | 2.96 | 0.94 | 1.43 | 1.00 | |||||
| vlPFC | 12.9 | 0.0001 * ** | 3.73 | 0.44 | |||||
* pBonferroni < .05, * * pBonferroni < .01, * ** pBonferroni < .001