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Histopathological evaluation of liver tissue using a modified Ishak score.
| Pathological changes | Naive | Male | Female |
|---|---|---|---|
| Periportal or periseptal interface hepatitis (piecemeal necrosis) | 0 | 1 | 1 |
| Confluent necrosis | 0 | 0 | 0 |
| Focal (spotty) lytic necrosis, apoptosis and focal inflammation | 1 | 2.2 ± 0.75 | 2.2 ± 0.75 |
| Portal inflammation | 0 | 2.2 ± 0.75 | 2.0 ± 2.0 |
| Fibrosis Stage (SR) staining | 0 | 1 | 1.4 ± 0.49 |
