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Selinexor does not affect the NETs formation machinery (A) Incubation of neutrophils with 50 nM Selinexor had no effect (A) on NE enzymatic activity (N = 3; p = 0.41); (B) MPO enzymatic activity (N = 3; p = 0.50) (C) PAD4 enzymatic activity (N = 3) and (D) oxidative burst (N = 3; p = 0.50).
