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. 2022 Nov 24;13:1042778. doi: 10.3389/fimmu.2022.1042778

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Copyright © 2022 Tang, Xiong, Fang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Weaning stress may affect intestinal homeostasis through microbial-driven short-chain fatty acids (SCFA) (By Figdraw). Weaning stress caused a reduction in SCFAs producing bacteria, such as Alloprevotella and Oscillospira (141), and an increase in the relative abundances of Erysipelotrichaceae and Lachnospiraceaet which is negatively correlated with butyrate production (121). SCFAs had a good regulatory effect on cell apoptosis (153), anti-inflammatory factors secretion (154), and tight junction proteins expression (155). Therefore, the intestinal dysfunction caused by weaning stress may be related to the secretion of SCFA driven by microorganisms.