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. 2022 Nov 4;14(12):evac161. doi: 10.1093/gbe/evac161

Fig. 4.

Fig. 4.

Recombination analysis of Betacoronavirus-1. (A) Nucleotide identity plot and multiple sequence alignment of BetaCoV-1 viruses. Orange dashed lines indicate divergent regions of the ECoV-NC99 genome while black dashed lines are regions with high identity to the reference sequence bovine coronavirus (BCoV). (B) ML tree of nsp2-encoding region of Orf1ab, which falls within the divergent ECoV-NC99 Region 2. (C) ML tree of the RdRp-encoding region of Orf1ab. (D) Schematic depicting the spike gene diversity of BetaCoV1 demonstrating the divergence of ECoV-NC99 and PHEV. Top BLAST hits in bolded red indicate no GenBank entries with >80% nucleotide identity.