Table 2.

Meta-regression on anxiety ES.

Variable(s)	B (95% CI)	p-value
Univariable analysis
Depression ES	2.59 (0.008; 5.17)	0.049
Days of follow-up	0.026 (−0.011; 0.063)	0.165
Age	0.056 (0.009; 0.104)	0.021
% Females	−0.002 (−0.049; 0.045)	0.931
Administration type
Adjuvant to ECT	0.162 (−1.22; 1.55)	0.819
IV treatment	−0.978 (−2.56; 0.604)	0.226
Spray treatment	−0.396 (-2.31; 1.52)	0.686
Dose applied
Esketamine 56 mg	−0.234 (−0.798; 0.331)	0.417
Ketamine 0.2 mg/kg	−2.21 (−3.71; −0.722)	0.004
Ketamine 0.5 mg/kg	0.010 (−0.678; 0.698)	0.978
TRD	0.444 (−0.823; 1.71)	0.493
Multivariable analysis
Age	0.035 (0.002; 0.068)	0.039
Depression ES	−0.739 (−3.84; 5.31)	0.752
Dose applied
Esketamine 56 mg	−1.85 (-3.40; −0.294)	0.020
Ketamine 0.2 mg/kg	−1.83 (−3.20; −0.471)	0.008
Ketamine 0.5 mg/kg	0.074 (0.002; 0.068)	0.714

B, unstandardized linear regression coefficient; 95% CI, 95% confidence interval; ES, effect size; IV, intravenous; TRD, treatment resistant depression.