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. 2022 Nov 24;13:1078678. doi: 10.3389/fimmu.2022.1078678

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Copyright © 2022 Garrido-Mesa, Thomas, Dodd, Spana, Perretti and Montero-Melendez

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Melanocortin receptors signaling induced by PL8177 and αMSH. Concentration dependent accumulation of cAMP (A) and formation of ERK1/2 phosphorylation (p-ERK1/2) (B) upon agonist stimulation (15 min for cAMP; 5min for p-ERK1/2) of HEK293A cells transiently transfected with mouse or human Melanocortin (MC) receptors. Data are expressed as percentage of maximal αMSH response and represent mean values of n=3 independent experiments, each one performed in duplicate.