Figure 5.

Effects of PL8177 in the K/BxN serum transfer induced arthritis (STIA) model Arthritis was induced by injecting mice with 100μl of K/BxN serum at days 0 and 2. A group of mice that did not receive serum was used as control (Ctrl). Mice were treated daily with vehicle (0mg/kg) or with PL8177 (0.3 or 3mg/kg) from day 2 to 7. Daily measurements of clinical score (A), paw volume (B) and knee width (C) are shown, together with the quantification of the area under the curve (AUC) calculated from days 2-7, corresponding to the duration of the treatments (bar graphs). (D) The percentage of mice developing moderate-severe arthritis (score ≥ 6) is presented. Representative images of the hind paws at day 7 are shown in (E) Data represent mean ± SEM of n=6-8 mice analysed by one-way ANOVA followed by multiple comparison test. *p<0.05 vs. vehicle group (0mg/kg).