Table 1.
Baseline patient characteristics, overall and stratified by consensus treatment plan choice
| Characteristic | All Patients | Biologic CTP IL-1i/IL-6i |
Non-Biologic CTP GC/Methotrexate |
|---|---|---|---|
| Number of Patients | 73 | 63 | 10 |
| Age in years (median (IQR)) | 6.8 (4.1, 11.0) | 7.0 (4.0, 11.3) | 6.2 (5.6, 7.8) |
| Male sex (%) | 44 (60.3) | 40 (63.5) | 4 (40.0) |
| Patient-Reported Race/Ethnicitya | |||
| White (%) | 48 (65.8) | 43 (68.3) | 5 (50.0) |
| Black (%) | 7 (9.6) | 5 (7.9) | 2 (20.0) |
| Hispanic (%) | 14 (19.2) | 11 (17.5) | 3 (30.0) |
| Asian (%) | 6 (8.2) | 6 (9.5) | 0 (0.0) |
|
Days since symptom onset (mean (SD)) |
46.4 (63.5) | 49.3 (67.6) | 28.1 (18.3) |
|
Days since diagnosis (median (IQR)) |
2.0 (0.0, 8.0) | 1.0 (0.0, 8.0) | 5.5 (0.5, 7.0) |
|
Physician global assessment (mean (SD)) |
6.0 (2.2) | 6.3 (2.1) | 4.7 (2.8) |
|
Patient global assessment (mean (SD)) |
5.6 (3.3) | 5.7 (3.3) | 5.4 (3.6) |
|
Number of active joints (mean (SD)) |
6.6 (7.6) | 7.0 (8.0) | 4.1 (4.4) |
| sJIA manifestations prior to enrollment | |||
| Fever (%) | 73 (100.0) | 63 (100.0) | 10 (100.0) |
| Arthritis (%) | 73 (100.0) | 63 (100.0) | 10 (100.0) |
| Rash (%) | 70 (95.9) | 60 (95.2) | 10 (100.0) |
| Lymphadenopathy (%) | 24 (32.9) | 22 (34.9) | 2 (20.0) |
| Hepatomegaly or Splenomegaly (%) | 15 (20.5) | 13 (20.6) | 2 (20.0) |
| Serositis (%) | 7 (9.6) | 6 (9.5) | 1 (10.0) |
| Laboratory values at time of enrolment (median (IQR)) | |||
| ESR (mm/hr) | 73 (57, 97) | 71 (54, 97) | 88 (76, 90) |
| CRP (mg/L) | 15.4 (7.5, 58.1) | 16.4 (7.5, 58.1) | 13.5 (7.3, 51.4) |
| Ferritin (ng/mL) | 829 (249, 2603) | 884 (290, 2652) | 363 (81, 779) |
| Hemoglobin (g/dL) | 10.2 (9.1, 11.4) | 10.7 (9.1, 11.5) | 9.4 (9.0, 10.2) |
| White blood cell count (109/L) | 12.2 (8.5, 19.1) | 12.0 (8.4, 19.0) | 14.5 (10.6, 22.7) |
| Platelets (109/L) | 458 (353, 571) | 452 (353, 565) | 509 (375, 735) |
| CHAQ (mean (SD)) | 1.3 (1.0) | 1.4 (1.0) | 1.2 (0.9) |
| cJADAS-10 (median (IQR)) | 17.0 (10.5, 21.5) | 17.5 (12.0, 21.0) | 14.0 (8.0, 23.0) |
aMore than 1 race or ethnicity per patient could be reported