Table 3.
Hemodynamic variables
| Group | Time | |||
|---|---|---|---|---|
| T0 | T1 | T2 | T3 | |
| Heart rate (beats/min) | ||||
| CON | 89.0 (16.5) | / | / | / |
| ARDS | 90.0 (18.2) | 132.0 (8.5) | / | / |
| LTV | 73.0 (23.0) | 135.3 (11.8) | 93.9 (37.3) | 91.1 (31.5) |
| APRV | 67.3 (12.3) | 154.7 (46.5) | 94.1 (26.2) | 84.3 (13.3) |
| Systolic blood pressure (mmHg) | ||||
| CON | 132.0 (33.3) | / | / | / |
| ARDS | 137.0 (25.4) | 139.0 (8.5) | / | / |
| LTV | 140.4 (17.4) | 148.0 (7.5) | 129.5 (14.9) | 144.5 (26.1) |
| APRV | 128.9 (29.8) | 133.3 (28.9) | 120.3 (12.4) | 127.4 (12.6) |
| Diastolic blood pressure (mmHg) | ||||
| CON | 73.3 (32.1) | / | / | / |
| ARDS | 80.0 (14.4) | 92.5 (4.9) | / | / |
| LTV | 84.0 (11.9) | 88.3 (16.2) | 129.5 (14.9) | 83.6 (33.2) |
| APRV | 70.7 (25.5) | 82.3 (23.1) | 60.1 (12.4) | 84.4 (28.4) |
| Mean arterial pressure (mmHg) | ||||
| CON | 98.0 (43.3) | / | / | / |
| ARDS | 105.0 (18.0) | 110.0 (4.2) | / | / |
| LTV | 107.6 (14.5) | 109.0 (14.4) | 92.1 (17.9) | 108.3 (31.8) |
| APRV | 95.1 (29.1) | 103.7 (25.7) | 83.4 (11.7) | 95.3 (9.6) |
| Cumulative fluids (L) | ||||
| LTV | / | 2.6 (2.4) | 1.9 (1.1) | 2.9 (1.4) |
| APRV | / | 2.1 (1.5) | 1.8 (0.7) | 3.2 (1.8) |
| Unrine volume (mL) | ||||
| LTV | / | 77.9 (26.1) | 58.7 (33.5) | 63.1 (59.0) |
| APRV | / | 70.7 (52.1) | 100.1 (69.4) | 81.8 (41.8) |
Data are presented as the mean(standard deviation) of the values recorded at T0 (before severe ARDS modeling), T1 (after severe ARDS modeling), T2 (24 h mechanical ventilation after severe ARDS modeling) and T3(48 h mechanical ventilation after severe ARDS modeling); CON, control group; ARDS, severe acute respiratory distress syndrome group; LTV, low tidal volume ventilation group; APRV, airway pressure release ventilation group; *p < 0.05 compared to the LTV group at this time point in Kruskal–Wallis H-test