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. 2022 Dec 7;15:130. doi: 10.1186/s13048-022-01054-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — TMEM205 undergoes ligand and clathrin independent endocytic recycling and exosome trafficking. A Ab feeding in OVTOKO cells to reveal internalization kinetics of TMEM205. B For plasma membrane recycling assay, OVTOKO cells were incubated at 37 °C for 30 min with anti-TMEM205 Ab pre-conjugated with AF488-Fab. The remaining fluorescence from cells at each time point was measured by FCM and plotted as the percentage of pre-recycling samples. C Intracellular localization of internalized TMEM205. The internalized TMEM205 was visualized by secondary Ab and examined for co-localization with membrane markers by confocal microscopy for Rab11. Yellow arrowheads indicate vesicles showing co-localization of TMEM205 and Rab11, LAMP1 and RAB4. D NTA data of isolated exosomes from OVTOKO cells showing the size and particle concentration distribution plot of exosomes