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. 2022 Dec 7;22:469. doi: 10.1186/s12890-022-02272-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — miR-125b-5p reduces the sensitivity of NSCLC cells to DDP, thus leading to DDP resistance. A CCK8 assay was performed to detect DDP sensitivity in miR-125b-5p mimic/inhibitor-treated A549 cells upon stimulation with the indicated concentrations of DDP (0 μg/mL, 6.25 μg/mL). B, C Apoptosis analysis in A549 cells following transfection using miR-125b-5p mimic/inhibitor upon treatment with the indicated concentrations of DDP (0 μg/mL, 6.25 μg/mL). D CCK8 assay was performed to detect DDP resistance in miR-125b-5p mimic/inhibitor-treated A549/DDP cells upon stimulation with the indicated concentrations of DDP (0 μg/mL, 6.25 μg/mL). E, F Apoptosis analysis in A549/DDP cells following transfection with miR-125b-5p mimic/inhibitor upon treatment with the indicated concentrations of DDP. *p < 0.05, **p < 0.01, ***p < 0.05