Table 2. Docking Scores of Tadalafil and the Positive Control Indomethacin and Morphine to the Binding Sites of COX2, iNOS, nNOS, IL-1, IL-10, and TNF-α.
| binding site | drug | docking score |
|---|---|---|
| COX-2 | indomethacin | –7.7861 |
| morphine | –5.1289 | |
| tadalafil | –8.1797 | |
| iNOS | indomethacin | –5.7651 |
| morphine | –5.4792 | |
| tadalafil | –7.5008 | |
| nNOS | indomethacin | –7.2830 |
| morphine | –5.6352 | |
| tadalafil | –7.2616 | |
| IL-1 | indomethacin | –5.8541 |
| morphine | –4.8657 | |
| tadalafil | –6.6988 | |
| IL-10 | indomethacin | –5.6242 |
| morphine | –4.3563 | |
| tadalafil | –5.9004 | |
| TNF-α | indomethacin | –5.0875 |
| morphine | –4.1433 | |
| tadalafil | –5.4228 |