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The roles of Sirtuins in regulating adipocyte differentiation. PPARγ and C/EBPα are the master regulators of preadipocyte commitment and terminal differentiation. FOXO plays an important role in the integration of hormone-activated signaling pathways with the complex transcriptional cascade that promotes adipocyte differentiation. PPARγ, peroxisome proliferator-activated receptor γ; FOXO, forkhead box O.
