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The roles of SIRT1-SIRT6 in manipulating lipid mobilization. Lipid mobilization is comprised of lipogenesis and lipolysis. Large lipid droplets are separated into small ones to initial lipolysis. TGs stored in lipid droplets are mobilized by the hydrolytic action of the three main lipases of the adipocyte to release FFAs, which are broken down to produce energy through FAO. TGs, triglycerides; FFAs, free fatty acids; FAO, fatty acid oxidation.
