Figure 3.

SIRT1, SIRT3, and SIRT6 participate in the regulation of AT inflammation via different pathways. AT inflammation is initiated and sustained over time by dysfunctional adipocytes that secrete inflammatory adipokines and by infiltration of bone marrow-derived monocytes that signal via production of cytokines and chemokines. White AT is the major source of obesity-related inflammation; in turn, AT inflammation leads to IR and metabolic dysfunction. AT, adipose tissue; IR, insulin resistance.