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. 2022 Nov 3;2(11):1334–1343. doi: 10.1158/2767-9764.CRC-22-0172

FIGURE 2.

FIGURE 2

Duloxetine protects against OIPN by blocking oxaliplatin entry to DRG neurons. A, Effect of duloxetine on the transport of ASP in SGCs isolated from wild-type mice and OCT1/2(−/−) mice (n = 3 per group). B, Effect of duloxetine on the transport of oxaliplatin in SGCs isolated from wild-type mice (n = 3 per group). C, Influence of duloxetine administered 1 hour before oxaliplatin on mechanical allodynia in wild-type mice and OCT1/2(−/−) mice measured by VFH tests (n = 10 per group). D, Influence of duloxetine administered 1 hour after oxaliplatin on mechanical allodynia in wild-type mice measured by VFH tests (n = 5 per group). Data represent the percentage change from baseline and each bar represents the mean ± SEM of two independent experiments. *, P < 0.05; **, P < 0.01 versus corresponding control or baseline.