TABLE 1.
One-Tissue-Compartment Model VT and BPND Values in Selected Brain Regions Under Baseline and Blockade Conditions
| Region of interest | VT (mL/cm3) | BP ND | ||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | Co 101244 (0.25 mg/kg) | FTC-146 (0.027 mg/kg) | FTC-146 (0.125 mg/kg) | (VT − VND)/VND | ||||
| Monkey 1 | Monkey 2 | Monkey 1 | Monkey 2 | Monkey 1 | Monkey 2 | Monkey 1 | Monkey 2 | |
| Thalamus | 24.6 (39.6) | 23.3 | 10.4 (13.7) | 10.2 | 20.9 | 13.9 | 1.64 (2.1) | 2.20 |
| Cerebellum | 27.3 (50.3) | 25.5 | 10.8 (13.1) | 10.2 | 19.6 | 15.5 | 1.93 (2.9) | 2.50 |
| Cingulate cortex | 38.8 (59.5) | 32.3 | 12.6 (16.5) | 12.1 | 27.9 | 19.3 | 3.16 (3.6) | 3.44 |
| Frontal cortex | 31.1 (49.1) | 28.9 | 11.0 (13.8) | 10.7 | 20.9 | 17.3 | 2.34 (2.8) | 2.97 |
| Hippocampus | 32.1 (50.8) | 26.3 | 11.5 (14.6) | 10.6 | 24.0 | 16.2 | 2.44 (2.9) | 2.61 |
| Semiovale | 20.3 (30.9) | 16.9 | 10.6 (13.7) | 9.0 | 15.9 | 11.5 | 1.18 (1.4) | 1.32 |
Data in parentheses are for (R)-18F-OF-NB1 in 1 monkey; other data are for (S)-18F-OF-NB1 in 2 different monkeys. VND values were derived from GluN1/2B blocking scan using Co 101244.