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. 2022 Dec;63(12):1815–1821. doi: 10.2967/jnumed.121.263611

TABLE 1.

Therapy Response Assessment Criteria Based on Imaging

Non-PD
Response criteria Imaging Complete response Partial response Stable response PD
PCWG3 imaging CT (2) Disappearance of all lesions Decrease of ≥30% in sum of target lesions (without new lesion or nontarget lesion progression) Not meeting criteria for partial response, complete response, or progressive disease Increase of ≥20% in sum of target lesions, unequivocal progression of nontarget lesions, or appearance of new lesions
BS (14) Disappearance of all suggestive lesions No new lesion or appearance of <2 new lesions No new lesion or appearance of <2 new lesions Appearance of at least ≥2 new lesions confirmed on subsequent scan
EAU/EANM PSMA PSMA PET/CT (6) Disappearance of any lesion with tracer uptake Reduction of uptake and tumor PET volume by >30% Change in uptake and tumor PET volume by ≤30%, without evidence of new lesions Increase of uptake or tumor PET volume by >30%, appearance of ≥2 new lesions (with or without CT change), or both