TABLE 1.
Therapy Response Assessment Criteria Based on Imaging
| Non-PD | |||||
|---|---|---|---|---|---|
| Response criteria | Imaging | Complete response | Partial response | Stable response | PD |
| PCWG3 imaging | CT (2) | Disappearance of all lesions | Decrease of ≥30% in sum of target lesions (without new lesion or nontarget lesion progression) | Not meeting criteria for partial response, complete response, or progressive disease | Increase of ≥20% in sum of target lesions, unequivocal progression of nontarget lesions, or appearance of new lesions |
| BS (14) | Disappearance of all suggestive lesions | No new lesion or appearance of <2 new lesions | No new lesion or appearance of <2 new lesions | Appearance of at least ≥2 new lesions confirmed on subsequent scan | |
| EAU/EANM PSMA | PSMA PET/CT (6) | Disappearance of any lesion with tracer uptake | Reduction of uptake and tumor PET volume by >30% | Change in uptake and tumor PET volume by ≤30%, without evidence of new lesions | Increase of uptake or tumor PET volume by >30%, appearance of ≥2 new lesions (with or without CT change), or both |