FIGURE 3.

Reinstatement responding after 14 days of forced abstinence: effects of sex and prior self-administration condition. Data are shown as the average number (±SEM) of active lever presses during the first hour of the Reinstatement Test in male and female rats that had self-administered oxycodone in the escalation phase under LgA or ShA conditions or self-administered saline (Sal). Across treatment groups, females had higher levels of reinstatement responding than males (main effect of Sex). Further, treatment group dictated the level of reinstatement responding, with LgA > ShA > Sal (main effect of Treatment). ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, main effects of sex and treatment, as indicated by brackets. N: LgA (19 females, 20 males); ShA (15 females, 13 males); Sal (8 females, 6 males).