TABLE 1.
LPS antibodies elicited by SPA-TT conjugates in sera of adults and teenagers
| Ig | Conjugate | Age (yr) | No. | GM LPS antibody titera (25th to 75th percentiles) (EU) on days after vaccination:
|
||
|---|---|---|---|---|---|---|
| 0 | 42 | 180 | ||||
| IgG | SPA-TT1 | 18–44 | 10 | 1.26 (0.6–2.6) | 9.82 (4.7–15.6) | 3.73 (2.67–7.10) |
| SPA-TT2 | 18–44 | 10 | 1.69 (1.0–2.9) | 27.3 (8.65–54.1) | 8.28 (9.86–10.1) | |
| SPA-TT1 | 13–17 | 56 | 1.69 (0.98–2.69) | 12.8 (6.75–22.9) | 6.72 (4.25–11.6) | |
| SPA-TT2 | 13–17 | 52 | 1.70 (1.13–2.34) | 17.4 (10.3–22.6) | 7.37 (4.80–12.0) | |
| IgM | SPA-TT1 | 18–44 | 10 | 17.3 (8.32–31.5) | 35.2 (23.7–48.9) | 18.7 (11.9–39.5) |
| SPA-TT2 | 18–44 | 10 | 17.7 (11.3–26.4) | 42.3 (25.4–74.9) | 24.1 (16.4–30.6) | |
| SPA-TT1 | 13–17 | 56 | 20.7 (14.3–28.0) | 29.6 (20.6–37.9) | 21.9 (17.2–25.4) | |
| SPA-TT2 | 13–17 | 52 | 24.9 (17.8–32.5) | 37.3 (27.1–48.6) | 23.9 (21.4–28.9) | |
a
Serum standard is from a high-responder vaccinee and is assigned a value of 100 EU.