TABLE 5.
IgG levels of tetanus antitoxin elicited by SPA-TT conjugates in sera of volunteers
| Age (yr) | Conjugate | GM antitoxin level (25th to 75th percentiles) on days after vaccination:
|
Fold rise at 180 days | |||
|---|---|---|---|---|---|---|
| 0 | 42 | 70 | 180 | |||
| 18–44 | SPA-TT1 | 0.29 (0.12–0.59) | 0.57 (0.23–1.38) | NAa | 0.56 (0.25–1.01) | 1.9 |
| SPA-TT2 | 0.15 (0.09–0.16) | 0.33 (0.11–0.66) | NA | 0.48 (0.24–0.52) | 3.2 | |
| 13–17 | SPA-TT1 | 0.11 (0.07–0.15) | 0.24 (0.09–0.47) | NA | 0.24 (0.14–0.36) | 2.2 |
| SPA-TT2 | 0.11 (0.07–0.15) | 0.27 (0.15–0.31) | NA | 0.33 (0.20–0.50) | 3.0 | |
| 2–4 | SPA-TT2 | 0.47 (0.29–0.81) | 11.5 (8.31–20.8) | 6.73 (4.66–12.7) | 3.62 (2.54–5.19) | 7.7 |
| SPA-TT2b | 0.42 (0.25–0.73) | 8.76 (4.89–20.3) | 6.74 (3.61–17.2) | 4.10 (1.71–10.7) | 9.8 | |
a
NA, not applicable.
b
Received a second injection on day 42.