Figure 3.

The importance of considering group level data during clustering. This figure demonstrates the necessity of combining patient data for clustering. The top panel shows preoperative ADC data from 12 glioblastoma patients after clustering, demonstrating a histogram with a smooth gaussian shape. The bottom panel shows the results of clustering when data from only one individual patient is considered, revealing a more irregular histogram and different cut off values for each cluster. Corresponding cluster regions are displayed visually on the left of each panel. This technical consideration is of particular importance as it has implications for prospective habitat generation in validation cohorts, which is dependent on robust predefined cut offs.