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. Author manuscript; available in PMC: 2022 Dec 8.
Published in final edited form as: Neurobiol Aging. 2022 Mar 4;114:15–26. doi: 10.1016/j.neurobiolaging.2022.02.014

Figure 1.

Figure 1.

Relationship between cerebrovascular response to moderate-intensity exercise and global amyloid-beta (Aβ) burden. A higher CVR predicted lower Aβ deposition across all participants (p=.013) (A). In APOE4 carriers, individuals classified as having elevated Aβ (solid line) demonstrated a stronger negative effect of CVR on Aβ deposition compared to APOE4 carriers classified as nonelevated Aβ (broken line) (p=.032) (B). In APOE4 noncarriers, there were no significant differences in the effect of CVR on Aβ deposition between individuals with elevated versus nonelevated Aβ deposition (p=.272) (C).