Table 3.
Association of MIR31HG polymorphisms with alcohol-induced ONFH.
| SNP ID | Model | Genotype | Case | Control | Crude analysis | Adjusted analysis | ||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | |||||
| rs1332184 | Codominant | GG | 159 | 238 | 1.00 | 1.00 | ||
| AA | 30 | 33 | 1.36 (0.80-2.32) | 0.258 | 1.38 (0.81-2.35) | 0.240 | ||
| AG | 119 | 154 | 1.16 (0.85-1.58) | 0.361 | 1.15 (0.84-1.57) | 0.377 | ||
| Dominant | GG | 159 | 238 | 1.00 | 1.00 | |||
| AA+AG | 149 | 187 | 1.19 (0.89-1.60) | 0.241 | 1.19 (0.89-1.60) | 0.244 | ||
| Recessive | AG+GG | 278 | 392 | 1.00 | 1.00 | |||
| AA | 30 | 33 | 1.28 (0.76-2.15) | 0.347 | 1.30 (0.77-2.19) | 0.319 | ||
| Additive | ------ | ------ | ------ | 1.16 (0.93-1.46) | 0.191 | 1.17 (0.93-1.46) | 0.185 | |
| rs72703442 | Codominant | CC | 209 | 298 | 1.00 | 1.00 | ||
| AA | 7 | 10 | 1.00 (0.37-2.67) | 0.997 | 1.01 (0.38-2.70) | 0.985 | ||
| AC | 92 | 116 | 1.13 (0.82-1.57) | 0.460 | 1.13 (0.81-1.56) | 0.467 | ||
| Dominant | CC | 209 | 298 | 1.00 | 1.00 | |||
| AA+AC | 99 | 126 | 1.12 (0.82-1.54) | 0.483 | 1.12 (0.82-1.54) | 0.487 | ||
| Recessive | AC+CC | 301 | 414 | 1.00 | 1.00 | |||
| AA | 7 | 10 | 0.96 (0.36-2.56) | 0.939 | 0.97 (0.37-2.59) | 0.959 | ||
| Additive | ------ | ------ | ------ | 1.09 (0.82-1.45) | 0.546 | 1.09 (0.82-1.45) | 0.545 | |
| rs2025327 | Codominant | TT | 231 | 338 | 1.00 | 1.00 | ||
| CC | 10 | 5 | 2.88 (0.97-8.55) | 0.056 | 2.93 (0.99-8.69) | 0.053 | ||
| CT | 67 | 87 | 1.11 (0.77-1.59) | 0.569 | 1.12 (0.78-1.60) | 0.547 | ||
| Dominant | TT | 231 | 338 | 1.00 | 1.00 | |||
| CC+CT | 87 | 92 | 1.21 (0.85-1.71) | 0.288 | 1.22 (0.86-1.72) | 0.271 | ||
| Recessive | CT+TT | 298 | 420 | 1.00 | 1.00 | |||
| CC | 10 | 5 | 2.82 (0.95-8.33) | 0.061 | 2.86 (0.97-8.45) | 0.058 | ||
| Additive | ------ | ------ | ------ | 1.26 (0.93-1.71) | 0.131 | 1.27 (0.94-1.73) | 0.121 | |
| rs55683539 | Codominant | CC | 176 | 248 | 1.00 | 1.00 | ||
| TT | 18 | 32 | 0.79 (0.43-1.46) | 0.454 | 0.79 (0.43-1.46) | 0.452 | ||
| TC | 114 | 144 | 1.12 (0.82-1.53) | 0.493 | 1.11 (0.81-1.52) | 0.506 | ||
| Dominant | CC | 176 | 248 | 1.00 | 1.00 | |||
| TT+TC | 132 | 176 | 1.06 (0.79-1.42) | 0.715 | 1.05 (0.78-1.42) | 0.730 | ||
| Recessive | TC+CC | 290 | 392 | 1.00 | 1.00 | |||
| TT | 18 | 32 | 0.76 (0.42-1.38) | 0.369 | 0.76 (0.42-1.38) | 0.368 | ||
| Additive | ------ | ------ | ------ | 0.99 (0.78-1.26) | 0.939 | 0.99 (0.78-1.25) | 0.927 | |
| rs2181559 | Codominant | TT | 121 | 183 | 1.00 | 1.00 | ||
| AA | 46 | 57 | 1.22 (0.78-1.92) | 0.387 | 1.23 (0.78-1.93) | 0.372 | ||
| AT | 141 | 185 | 1.15 (0.84-1.58) | 0.380 | 1.15 (0.83-1.57) | 0.405 | ||
| Dominant | TT | 121 | 183 | 1.00 | 1.00 | |||
| AA+AT | 187 | 242 | 1.17 (0.87-1.58) | 0.306 | 1.16 (0.86-1.57) | 0.318 | ||
| Recessive | AT+TT | 262 | 368 | 1.00 | 1.00 | |||
| AA | 46 | 57 | 1.13 (0.75-1.72) | 0.558 | 1.15 (0.75-1.75) | 0.525 | ||
| Additive | ------ | ------ | ------ | 1.12 (0.90-1.38) | 0.307 | 1.12 (0.90-1.38) | 0.304 | |
| rs10965059 | Codominant | CC | 249 | 277 | 1.00 | 1.00 | ||
| TT | 2 | 8 | 0.28 (0.06-1.32) | 0.108 | 0.27 (0.06-1.28) | 0.098 | ||
| TC | 55 | 137 | 0.45 (0.31-0.64) | <0.001 | 0.43 (0.30-0.62) | <0.001 | ||
| Dominant | CC | 249 | 277 | 1.00 | 1.00 | |||
| TT+TC | 57 | 145 | 0.44 (0.31-0.62) | <0.001 | 0.42 (0.30-0.61) | <0.001 | ||
| Recessive | TC+CC | 304 | 414 | 1.00 | 1.00 | |||
| TT | 2 | 8 | 0.34 (0.07-1.62) | 0.175 | 0.33 (0.07-1.59) | 0.169 | ||
| Additive | ------ | ------ | ------ | 0.46 (0.33-0.64) | <0.001 | 0.45 (0.32-0.62) | <0.001 | |
| rs10965064 | Codominant | CC | 128 | 171 | 1.00 | 1.00 | ||
| GG | 39 | 60 | 0.87 (0.55-1.38) | 0.551 | 0.87 (0.54-1.38) | 0.545 | ||
| GC | 141 | 194 | 0.97 (0.71-1.33) | 0.855 | 0.97 (0.71-1.33) | 0.857 | ||
| Dominant | CC | 128 | 171 | 1.00 | 1.00 | |||
| GG+GC | 180 | 254 | 0.95 (0.70-1.28) | 0.719 | 0.95 (0.70-1.28) | 0.719 | ||
| Recessive | GC+CC | 269 | 365 | 1.00 | 1.00 | |||
| GG | 39 | 60 | 0.88 (0.57-1.36) | 0.570 | 0.88 (0.57-1.36) | 0.562 | ||
| Additive | ------ | ------ | ------ | 0.94 (0.76-1.17) | 0.588 | 0.94 (0.76-1.17) | 0.584 | |
SNP, single nucleotide polymorphism; OR, odds ratio; 95% CI, 95% confidence interval.
p values were calculated by logistic regression analysis.
Bold values indicate statistical significance (p < 0.05).