Table 1:

Clinical overview of the included patients with pathology-confirmed DLBC EBV-positive CNS lymphoma

	Age (yr)	Sex	Underlying Conditions	Radiologic Diagnosisa	Diagnostic-Therapeutic Initial Management
P 1	66	Male	Kidney transplant	Multiple metastasesb	Biopsy: reason, multiple lesions
P 2	76	Male	Chronic myeloproliferative disorder; essential thrombocythemia	Glioblastoma	Biopsy: reason, patient basal clinical status
P 3	74	Male	Liver transplant	Single metastasisc	Biopsy: reason, second-look radiologic opinion
P 4	62	Female	Systemic sclerosis and discoid cutaneous lupus	Glioblastoma	Maximal safe surgical resection
P 5	70	Female	Immunosenescence	Multiple metastases or multifocal glioblastoma	Biopsy: reason, multiple lesions
P 6	63	Male	Autoimmune hepatitis	Metastasis or glioblastoma	Maximal safe surgical resection
P 7	78	Female	Kidney transplant	Single metastasis	Maximal safe surgical resection

Note:—P indicates patient.

^aBased on a radiologic report from our neuro-oncology reference tertiary university hospital.

^bAtypical infection was considered, but as an unlikely option.

^cA second-look opinion raised the possibility of atypical lymphoma.