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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Mol Cell. 2022 Nov 16;82(23):4428–4442.e7. doi: 10.1016/j.molcel.2022.10.025

Figure 4. PAX3-FOXO1 recruits complexes involved in transcription.

Figure 4.

(A) Volcano plot showing log2-fold change (PAX3-FOXO1-APEX2/Parental) vs. −log10 of the p-value generated from the mass spectrometry results of PAX3-FOXO1-APEX2-mediated biotinylation (n=3, one-tail unpaired T-test). Blue dots, enriched in parental samples; red dots, enriched in PAX3-FOXO1-APEX2 samples. (B) Heatmaps of selected PAX3-FOXO1-APEX2 biotinylated proteins from the APEX2-mass spectrometry analysis. Total spectral count is shown within each box. (C) Heatmaps of CUT&RUN analysis of representative factors from the analysis in B plotted around all PAX3-FOXO1 binding sites.