TABLE 1.
Baseline parameters in patients receiving only ACE‐inhibitors (ACE‐I), ARB or none of these compounds
| No ACE‐I/no ARB | ACE‐I /no ARB | No ACE‐I /ARB | ||
|---|---|---|---|---|
| Variable | (N = 1416) | (N = 1717) | (N = 118) | P* |
| Age (years) | 60.8(11.4) | 63.9(9.94) | 66.2(8.96) | <0.001 |
| Female sex (%) | 32.1 | 28.3 | 35.6 | 0.070 |
| BMI (kg/m2) | 27(3.62) | 27.8(4.32) | 28.7(4.11) | <0.001 |
| LDL‐C (mg/dl) | 120(35.3) | 114(33.4) | 113(33.2) | <0.001 |
| HDL‐C (mg/dl) | 40.2(11) | 37.5(10.5) | 40.4(11.5) | <0.001 |
| TG (mg/dl) | 144(105‐200) | 148(112‐201) | 150(114‐193) | 0.024 |
| SBP (mmHg) | 139(21.8) | 143(24.7) | 148(24.7) | <0.001 |
| DBP (mmHg) | 80.5(10.8) | 81.4(11.8) | 82.6(12.5) | 0.044 |
| Creatinine | 0.953(0.466) | 0.987(0.263) | 0.978(0.236) | <0.001 |
| Cystatin C | 0.938(0.399) | 1.03(0.385) | 1.03(0.271) | <0.001 |
| Uromodulin | 171(77.4) | 148(70.1) | 148(73.1) | <0.001 |
| Central PP | 69.2(19.8) | 70.8(22.1) | 78.1(24.6) | 0.001 |
| PP | 58.5(16.9) | 61.3(19) | 65.2(18) | <0.001 |
| DP | 9530(2350) | 9820(2470) | 10200(2260) | <0.001 |
| MAP | 100(13.2) | 102(14.7) | 104(15.3) | <0.001 |
| Renin (pg/ml) | 8.98(4.79‐16.2) | 14.4(6.59‐33.5) | 14.1(7.34‐36.1) | <0.001 |
| Aldosterone (ng/l) | 83(52‐126) | 72.5(45‐116) | 84(52.2‐133) | <0.001 |
| Angiotensinogen (nnmol/l) | 1200(943‐1520) | 1130(845‐1450) | 1160(804‐1450) | <0.001 |
| Angiotensin‐I (ng/l) | 1550(1220‐1980) | 1460(1100‐1880) | 1500(1040‐1880) | <0.001 |
| Angiotensin‐II (ng/l) | 19(12‐32) | 20(13‐37) | 24(15‐36.5) | <0.001 |
| ACE (U/l) | 30(23‐39) | 14(8‐27) | 33(24.2‐41) | <0.001 |
| Adrenalin (ng/l) | 36(22‐57) | 34(22‐55) | 35(22‐54) | <0.001 |
| Noradrenalin (ng/l) | 292(205‐416) | 318(217‐454) | 360(254‐448) | <0.001 |
| Aldosterone / Renin | 5.12(2.84‐9.33) | 2.86(1.14‐6.24) | 3.01(1.41‐6.73) | <0.001 |
| NT‐proBNP (pg/ml) | 171(74‐458) | 437(160‐1230) | 310(145‐790) | <0.001 |
| Coronary artery disease (%) | 68.9 | 85.3 | 75.4 | <0.001 |
| Diabetes mellitus (%) | 32.6 | 44 | 52.5 | <0.001 |
| Smoking (current or ex, %) | 62.8 | 67 | 53.4 | 0.005 |
*ANOVA for continuous variables, non‐normally distributed variables were log‐transformed before entering analyses, and chi‐square test for categorical variables.
Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; DP, double product; MAP, mean arterial pressure; ACE, angiotensin Converting Enzyme; CAD, Coronary artery disease.