TABLE 2.
Induction of IgG2 by PAFa
| PAF concn (nM) | NP PBL
|
LJP PBL
|
||||
|---|---|---|---|---|---|---|
| IgG2 induction (%) | n | P | IgG2 induction (%) | n | P | |
| Control | 100 | 7 | 100 | 4 | ||
| 10 | 144 ± 15b | 7 | <0.03 | 98 ± 4 | 4 | NSc |
| 100 | 123 ± 3b | 7 | <0.01 | 105 ± 5 | 4 | NS |
| 1,000 | 122 ± 22 | 6 | NS | 103 ± 3 | 4 | NS |
The data were normalized by presenting the results as the percentages of the IgG2 response of NP or LJP PBL cultured in the absence of PAF. Thus, the control response in the absence of PAF equals 100%. The 100% response for NP subjects was 339 ng of IgG2/ml, and individual results ranged from 160 to 570 ng/ml. For LJP subjects, the 100% response was 1,020 ng of IgG2/ml, and individual results ranged from 480 to 1,800 ng/ml. Means ± standard errors are shown.
Significantly different from control PBL.
NS, not significantly different from PBL.