Table 2.
Clinical characteristics and comparison between different categories among 24 IPN patients with MDR-GNB bacteraemia.
| Characteristics | Moderately SAP (n = 8) | SAP (n = 16) | p-Value |
|---|---|---|---|
| Age, years (mean ± SD) | 53.3 ± 13.9 | 46.9 ± 11.4 | 0.247 |
| Sex, n (%) | 1.000 | ||
| Male | 6 (75.0) | 13 (81.2) | |
| Female | 2 (25.0) | 3 (18.8) | |
| Aetiology, n (%) | 0.113 | ||
| Hypertriglyceridemia | 6 (75.0) | 5 (31.3) | |
| Biliary | 2 (25.0) | 9 (56.2) | |
| Others | 0 | 2 (12.5) | |
| Concomitant infections, n (%) | 3 (37.5) | 6 (37.5) | 1.000 |
| Onset of bacteraemia, n (%) | 0.096 | ||
| Pre-intervention | 0 | 3 (18.8) | |
| Post-intervention (≤5 days) | 3 (37.5) | 9 (56.2) | |
| Post-intervention (> 5 days) | 5 (62.5) | 4 (25.0) | |
| Intervention, n (%) | 0.789 | ||
| PCD | 1 (12.5) | 2 (12.5) | |
| PCD—minimal access retroperitoneal necrosectomy | 4 (50.0) | 11 (68.8) | |
| OPN | 1 (12.5) | 1 (6.2) | |
| Step-up to OPN | 2 (25.0) | 2 (12.5) | |
| Laboratory and clinical variables (mean ± SD) | |||
| Albumin, g/L | 29.8 ± 3.2 | 30.6 ± 4.0 | 0.631 |
| Neutrophil count, 103/mm3 | 7.2 ± 4.6 | 12.3 ± 9.1 | 0.152 |
| Lymphocyte count, 103/mm3 | 0.8 ± 0.7 | 1.0 ± 1.6 | 0.807 |
| Procalcitonin, ng/L | 5.1 ± 5.2 | 35.5 ± 46.2 | 0.020* |
| Highest temperature, °C | 39.2 ± 0.7 | 39.0 ± 1.0 | 0.690 |
| Inappropriate empirical therapy | 3 (37.5) | 5 (31.3) | 0.761 |
| Antibiotic therapy, n (%) | 0.885 | ||
| Monotherapy | 5 (62.5) | 8 (50.0) | |
| Polytherapy | 3 (37.5) | 8 (50.0) | |
| Mortality, n (%) | 2 (25.0) | 13 (81.3) | 0.025* |
IPN, infected pancreatic necrosis; MDR-GNB, multiple drug-resistant Gram-negative bacterial; SAP, severe acute pancreatitis; PCD, percutaneous catheter drainage; OPN, open necrosectomy.
*p-Values are statistically significant between moderately SAP and SAP groups among MDR-GNB bacteraemia patients.