TABLE 1.
Summary statistics for general population controls, Eosinophilic esophagitis (EoE) patients and their siblings
| Controls a | EoE | Sibling | EoE | |
|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | |
| Total | 7660 (100.00) | 1587 (100.00) | 2045 (100.00) | 1214 (100.00) |
| Male | 5744 (74.99) | 1189 (74.92) | 1049 (51.30) | 914 (75.29) |
| Female | 1916 (25.01) | 398 (25.08) | 996 (48.70) | 300 (24.71) |
| Age at diagnosis or matching | ||||
| Mean [SD] years | 36.14 (19.54) | 36.95 (19.91) | 36.75 (19.40) | 35.50 (18.61) |
| Median [IQR] years | 37.00 (18.00–51.00) | 38.00 (19.00–52.00) | 38.00 (21.00–51.00) | 36.00 (19.00–50.00) |
| <18 years | 1810 (23.63) | 365 (23.00) | 426 (20.83) | 285 (23.48) |
| > = 18 years | 5850 (76.37) | 1222 (77.00) | 1619 (79.17) | 929 (76.52) |
| Year of diagnosis | ||||
| 2000–2010 | 305 (19.22) | 224 (18.45) | ||
| 2011–2017 | 1282 (80.78) | 990 (81.55) | ||
| Country of birth | ||||
| Nordic | 6415 (83.75) | 1508 (95.02) | 1972 (96.43) | 1188 (97.86) |
| Other | 1244 (16.24) | 79 (4.98) | 73 (3.57) | 26 (2.14) |
| NA | 1 (0.01) | 0 (0.00) | 0 (0.00) | 0 (0.00) |
| Education | ||||
| Compulsory school, (< = 9 years) | 1441 (18.81) | 247 (15.56) | 297 (14.52) | 172 (14.17) |
| Upper secondary school (10–12 years) | 2711 (35.39) | 563 (35.48) | 735 (35.94) | 430 (35.42) |
| College or university (> = 13 years) | 1992 (26.01) | 493 (31.06) | 633 (30.95) | 389 (32.04) |
| NA | 1516 (19.79) | 284 (17.90) | 380 (18.58) | 223 (18.37) |
| Infectious exposure | ||||
| Any | 1793 (23.41) | 564 (35.54) | 593 (29.00) | 427 (35.17) |
| Respiratory | 960 (12.53) | 305 (19.22) | 310 (15.16) | 237 (19.52) |
| Gastrointestinal | 268 (3.50) | 128 (8.07) | 88 (4.30) | 95 (7.83) |
| Urinary | 172 (2.25) | 68 (4.28) | 84 (4.11) | 49 (4.04) |
| Skin | 336 (4.39) | 117 (7.37) | 111 (5.43) | 84 (6.92) |
| Other | 600 (7.83) | 225 (14.18) | 232 (11.34) | 175 (14.42) |
| Opportunistic | 27 (0.35) | 9 (0.57) | 15 (0.73) | 7 (0.58) |
| Sepsis | 21 (0.27) | 14 (0.88) | 5 (0.24) | 5 (0.41) |
| Age at first exposure | ||||
| Mean [SD] years | 22.89 (21.76) | 21.01 (20.35) | ||
| Median [IQR] years | 18.35 (1.74–38.08) | 15.36 (1.66–36.19) | ||
| <18 years | 917 (51.14) | 281 (49.82) | 276 (46.54) | 224 (52.46) |
| > = 18 years | 876 (48.86) | 283 (50.18) | 317 (53.46) | 203 (47.54) |
| Number of infections | ||||
| 1 | 925 (12.08) | 233 (14.68) | 263 (12.86) | 172 (14.17) |
| 2 | 309 (4.03) | 99 (6.24) | 120 (5.87) | 82 (6.75) |
| > = 3 | 366 (4.78) | 180 (11.34) | 145 (7.09) | 138 (11.37) |
| Earlier autoimmunity b | ||||
| No | 7307 (95.39) | 1458 (91.87) | 1912 (93.50) | 1128 (92.92) |
| Yes | 353 (4.61) | 129 (8.13) | 133 (6.50) | 86 (7.08) |
a
Controls = general population control.
b
Autoimmunity up until EoE diagnosis. Autoimmune disorders included in the concept autoimmunity: diabetes mellitus, psoriasis, SLE, rheumatoid arthritis, thyroiditis, hyperthyroidism, sarcoidosis, primary biliary cirrhosis, ANCA vasculitis and other vasculitis, pelvospondylitis, autoimmune hepatitis, primary sclerosing cholangitis, celiac disease.