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. 2022 Nov 24;16:992130. doi: 10.3389/fnins.2022.992130

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Copyright © 2022 Li, Ni, Qi, Li, Yang and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Duloxetine increases serotonin concentration while deactivating glutamatergic neurons in anterior cingulate cortex (ACC). (A) Schematic diagram of the experimental procedure for fiber photometry of 5-HT sensor fluorescence signals and Ca²⁺ signal recording of CaMKIIa-Gcamp6s of mice ACC. (B) Image of CaMKIIa-Gcamp6s and the fiber channel in ACC. (C) Fluorescence changes of CaMKIIa-Gcamp6s in ACC after the intraperitoneal injection of duloxetine. (D) Average ΔF/F after saline and duloxetine injection (Duloxetine n = 5, saline n = 4, p = 0.0434, unpaired t-test). (E) Image of the 5-HT sensor and the fiber channel in ACC. (F) Fluorescence changes of the 5-HT sensor in ACC after the intraperitoneal injection of duloxetine. (G) Average ΔF/F after saline and duloxetine injection (n = 4, p = 0.0083, unpaired t-test).