Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 18;9(34):2202342. doi: 10.1002/advs.202202342

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

The mAbs engage hIAPP protofibrils in human T2D. Immunofluorescence shows increased hIAPP protofibril staining in pancreatic islet tissue from a T2D donor compared to nondiabetic control with a) 07G10 and b) 10H04. c) Magnified inset shows co‐localization of protofibril signal and hIAPP aggregate signal detected by ThS staining with protofibril signal localized at the core of larger aggregates. mAb (magenta), ThS (yellow), nuclei (cyan). Co‐localization of protofibril signal and ThS signal is indicated by white arrowheads.