Figure 6.

The mAbs protect islets from macrophage‐driven β cell destruction. a) Immunofluorescence imaging of pancreatic islets from WT, vehicle‐control, and mAb‐treated mice showing that mAb treatment preserved the islet health of treated mice. Insulin (magenta), mAb (yellow), nuclei (cyan). b) Immunofluorescence imaging of pancreatic islets from WT, vehicle‐control, and mAb‐treated mice showing mAb treatment prevented islet apoptosis cleaved caspase 3 (magenta), mAb (yellow), and nuclei (cyan). c) Immunofluorescence imaging of pancreatic islets from WT, vehicle‐control, and mAb‐treated mice showing mAb treatment prevented increased macrophage infiltration seen with diabetic mice. Macrophage (magenta), mAb (yellow), nuclei (cyan). n = 2 per group, technical triplicates; error bars represent S.E.M.; ordinary one‐way ANOVA. ****p < 0.0001, ***p < 0.001, and **p < 0.01, ns = not significant.