FIGURE 4.

Reduced fractional anisotropy (FA) in the dorsal striatum of histidine decarboxylase-knockout (Hdc-KO) mice. Top rows: Coronal sections from the reference atlas to which diffusion tensor imaging (DTI) information was registered for analysis. Middle rows: FA in adult male WT and Hdc-KO mice (n = 6 per genotype). Striatum is indicated by arrowheads. Bottom row: Whole-brain corrected voxel-wise t-test comparison revealed reduced FA in the dorsal striatum of Hdc-KO mice, more prominently on the right. There were no regions of increased FA in Hdc-KO mice. N = 6 WT, 6 KO.