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. 2022 Nov 12;298(12):102695. doi: 10.1016/j.jbc.2022.102695

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Proposed catalytic mechanism for HsIDH3. (1) NAD reduction (2). Decarboxylation on the C_β atom and double bond rearrangement (3). Protonation on the C_β atom and release of CO₂ (4). Release of the product. Catalytic residues are numbered according to the αβ heterodimer of HsIDH3.