Figure 7.
Baicalin and EDTA rescues colistin activity in three animal infection models. Decreased bacterial load in the mouse abdominal cavity infection model by combination therapy. Female KM mice (n=6 per group) were intraperitoneally infected given a non-lethal dose of Salmonella SR04 and SR14 (mcr-1) (1.0 × 105 cfus), and treated with a single dose of colistin(20 mg/kg), colistin + baicalin (20 + 50 mg/kg), colistin + EDTA (20 + 10 mg/kg) or a combination of the three drugs (20 + 50 + 10 mg/kg), or PBS by intraperitoneal injection. P values were determined by Mann-Whitney U test. P values (*P < 0.05, **P < 0.01 and ***P < 0.001) are reported. Data are presented as mean ± SD.