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. 2022 Nov 26;66:101647. doi: 10.1016/j.molmet.2022.101647

Figure 1.

Figure 1

Insulin and IGF-1 potently regulate transcription in astrocytes. A. Principal component analysis (PCA) of transcriptomes in primary cultured astrocytes at baseline or following 100 nM insulin or IGF-1 stimulation for 6 h. B. Pearson correlation showing transcriptional groupings for control, insulin-stimulated and IGF-1-stimulated astrocytes. C. VENN diagram showing unique and common genes regulated by insulin or IGF-1 (FDR < 0.05, |FC| > 1.5). Numbers in the square bracket indicate the up-regulated genes versus down-regulated genes. D. Scattered plot showing ligand stimulated transcriptional changes by insulin and IGF-1. Gray dots represent commonly regulated genes. Blue dots represent insulin-specific regulations, whereas red dots represent IGF-1-specific regulations. E. Heatmap of all significantly regulated genes (FDR < 0.05, |FC| > 1.5) and clustered by their responses to insulin and IGF-1.