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. 2022 Nov 26;66:101647. doi: 10.1016/j.molmet.2022.101647

Figure 3.

Figure 3

IR-dependent gene regulations. A. Principal component analysis (PCA) of transcriptomes in IR-flox and insulin receptor knockout (IRKO) astrocytes with or without 100 nM insulin stimulation for 6 h. B. Pearson correlation showing the clusters of the four distinct conditions. C. VENN diagram showing significantly up- or down-regulated genes by insulin in the presence and absence of IR (FDR < 0.05, |FC| > 1.5). Numbers in the square bracket indicate the up-regulated genes versus down-regulated genes. D. Scattered plot showing insulin-stimulated transcriptional changes in IR-flox and IRKO astrocytes. Gray dots represent genes regulated by insulin in both IR-flox and IRKO astrocytes. Green dots represent genes regulated by insulin specifically in IR-flox astrocytes, while purple dots represent genes regulated only in IRKO astrocytes. E. Heatmap of all significantly regulated genes (FDR < 0.05, |FC| > 1.5) and clustered by the responses in different cell types.