Table 1.
Summary of publicly available GDS datasets for pancreatic islets and purified β-cells suggests Pck1 is expressed in β-cells.
| GEO profile | Organism | Citation | Pck1 in islets/β-cells | Comments |
|---|---|---|---|---|
| GDS4934 | Mus musculus | [80] | β-cells | Pck1 is expressed in alpha, beta cells and beta cells from Pdx1 KO |
| GDS4935 | Rattus norvegicus | [81] | β-cells | Pck1 is expressed in alpha, beta cells and β-cells from Pdx1 overexpression |
| GDS4937 | Rattus norvegicus | [82] | β-cells | Pck1 is expressed at higher levels in 2-3 day neonates β-cells compared to 10 week adults |
| GDS4942 and GDS4939 | Mus musculus | [83] | Islets | Pck1 is expressed in pancreatic islets young and adults mice cultured in low and high glucose |
| GDS4320 | Mus musculus | [84] | Islets | Pck1 is expressed in control and PPARβ/δ |
| GDS4337 | Homo Sapiens | [[85], [86], [87], [88]] | Islets | Pck1 is expressed in pancreatic islets from T2D and Control donors |
| GDS3983 | Homo Sapiens | [89] | Islets | Pck1 is expressed in pancreatic endocrine cells, at lower levels compared with colon, kidney and small intestine |
| GDS3984 | Homo Sapiens | [90] | Islets | Pck1 is expressed in islets, dedifferentiated and redifferentiated islets |
| GDS3991 | Mus musculus | [91] | β-cells | Pck1 is expressed in β-cells at time of isolation as well as 24h and 48h past isolation |
| GDS4116 | Mus musculus | [92] | β-cells | Pck1 is expressed in islets and in purified β-cells from Rag-/- mice |
| GDS5618 | Mus musculus | [93] | Islets | Higher expression of Pck1 in islet graft |
| GDS4933 | Mus musculus | [94] | Islets | Pck1 is expressed in conditional activation of IKK2/NF-κB in pancreatic beta-cells and control islets |
| GDS5380 | Mus musculus | [95] | β-cells | Pck1 is expresses in control and Irs1 knock out islets with or without Tungstate. |