TABLE 2.
Univariate and multivariate analyses of risk factors associated with mortality in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients.
| Univariate |
Multivariate |
|||||
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Sex | ||||||
| Female | Reference | |||||
| Male | 1.057 | 0.478–2.339 | 0.891 | |||
| WBC (109/L) | 1.059 | 0.999–1.122 | 0.053 | |||
| PLT (109/L) | 0.993 | 0.988–0.999 | 0.013 | |||
| ALT (μ/L) | 1.001 | 0.999–1.002 | 0.397 | |||
| AST (μ/L) | 1.002 | 0.998–1.003 | 0.145 | |||
| TC (mg/dL) | 0.983 | 0.975–0.992 | <0.001 | |||
| HDL-C (mg/dL) | 0.811 | 0.730–0.900 | <0.001 | 0.806 | 0.724–0.898 | <0.001 |
| CTPs | 1.685 | 1.418–2.002 | <0.001 | 1.424 | 1.143–1.775 | 0.002 |
| MELDs | 1.158 | 1.022–1.196 | 0.002 | 1.006 | 1.002–1.007 | 0.048 |
| COSSH-ACLF IIs | 1.886 | 1.532–2.321 | <0.001 | 1.609 | 1.005–2.575 | 0.025 |
P-value < 0.05 was considered significant and was indicated in bold. WBC, white blood cell count; PLT, platelet; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; CTPs, child-turcotte-pugh score; MELDs, model for end-stage liver disease score; COSSH-ACLF IIs, Chinese Group on the Study of Severe Hepatitis B-ACLF II score.