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. 2022 Dec 8;5:1350. doi: 10.1038/s42003-022-04297-6

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© The Author(s) 2022, corrected publication 2022

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Fig. 2 — The GS topography is significantly altered in the different phases of bipolar disorder, with increased GSCORR in hippocampus (and parahippocampus/fusiform gyrus) in bipolar depression and motor cortex in bipolar mania (from Zhang et al.²²). In major depressive disorder, the GS topography is increased in default-mode regions that shows abnormally strong global functional connectivity with all other regions, i.e., non-DMN in the rest of the brain (from Scalabrini et al.⁸⁹). GS Global signal, GSCORR Global signal correlation, C Control group, D Depression, M Mania, E Euthymic, MDD Major depressive disorder, HC Healthy control, GSR Global signal regression.