Table 1.
List of childhood asthma associated miRNAs
| Adult/childhood | miRNA ID | Target gene | Function | Sample | Reference (PubMed ID) | Review/research |
|---|---|---|---|---|---|---|
| Childhood | miR-145-5p | NA | Associated with the early decline patterns of lung function growth leading to COPD in children with asthma and additionally increases airway smooth muscle cell proliferation | Serum | 33385444 | Research |
| Childhood | miR-196a2 | ANXA1 | miR-196a2 expression and serum ANXA1 concentration may play a role in the pathogenesis of asthma | Serum | 32279913 | Research |
| Childhood | miR-15a | NA | Role in the fetal origin of asthma | Fetal lung | 33291534 | Research |
| Childhood | miR-146a, miR-106b | NA | Aberrant expression of immune-related microRNAs in pediatric patients with asthma | Plasma | 33688482 | Research |
| Childhood | miR-33a, miR-495 | NA | lncRNAs correlated negatively with miR-33a and miR-495 and positively with inflammatory cytokines in asthmatic children | Blood | 34288494 | Research |
| Childhood | miR-328-3p, let-7d-3p | NA | Seasonal variation in miR-328-3p and let-7d-3p are associated with seasonal allergies and asthma symptoms in children | Serum | 34212545 | Research |
| Childhood | miR-103 | NA | Baicalin regulates the onset of asthma in children by up-regulating microRNA-103 and modulating the TLR4/NF-B pathway | Mouse | 33730981 | Research |
| Childhood | miR-206 | CCL2 | Pro-inflammatory and pro-fibrotic role of lncRNA RMRP in pediatric asthma through targeting microRNA-206/CCL2 axis | Pulmonary tissue | 33511814 | Research |
| Childhood | miRs:221-5p, 139-3p, 96-5p, 6641-5p, 199b-5p, 151b, 1307-3p, 148a-5p | NA | Childhood asthma remission | Serum | 32888944 | Research |
| Childhood | miR-451a | ETS1 | Down-regulation of miRNA-451a promotes the differentiation of CD4+ T cells toward Th2 cells by up-regulating ETS1 in childhood asthma | Lymphocytes | 33271553 | Research |
| Childhood | miR-192 | CXCR5 | Decreased miR-192 in blood of asthmatics | NA | 32777705 | Review |
| Childhood | miR-27b-3p | SYK, EGFR, IL-12 | Modulation of PI3K-Akt signaling pathway | Blood | 33460581 | Review |
| Childhood | miR-143a | NA | Regulation of polymorphonuclear neutrophil counts | Sputum | 33460581 | Review |
| Childhood | miR-223a | NA | Attenuation of the airway neutrophil responses | Sputum | 33460581 | Review |
| Childhood | miR-21 | IL-12p35 | Production and activation of inflammatory cells | Serum | 33460581 | Review |
| Childhood | miR-221 | Spred | Regulation of mast cells functions | Blood | 33460581 | Review |
| Childhood | miR-485-3p | NA | Regulation of airway hyperresponsiveness | Blood | 33460581 | Review |
| Childhood | miR-21-5p | IL-12 | Dysregulation of Th1/Th2 production | Bronchial epithelial cells | 33460581 | Review |
| Childhood | miR-146a-3p | NA | Up-regulation of small airway reversibility | Bronchial epithelial cells | 33460581 | Review |
| Childhood | miR-155-5p | CCL11, CCL26, IL-13 | Inhibition of eosinophil production | Bronchial epithelial cells | 33460581 | Review |
| Childhood | miR-485-3p | SPRED-2 | Airway remodeling by decreasing sprout-related EVH1 domain-containing protein (spred)-2 expression to promote growth factor-mediated Ras/ERK activation | ASMCs | 34359876 | Review |
| Childhood | miR-155 | NA | A biomarker of worsened lung function | Serum/plasma | 33478047 | Review |
| Childhood | miR-16 | NA | A significant negative correlation with FEV1 | Serum/plasma | 33478047 | Review |
| Childhood | miR-199a-5p | NA | Increased in plasma and sputum of patients with neutrophilic asthma. Negative correlation with pulmonary function | Serum/plasma | 33478047 | Review |
| Childhood | miR-146b, miR-206, miR-720 | NA | NF-kβ and GSK3/AKT pathways, might improve the accuracy of asthma exacerbation risk prediction in a pediatric asthma | Serum | 33214212 | Review |
| Childhood | miR-15b, miR-126, miR-139, miR-142, miR-186, miR-191, miR-342, miR-374a, miR-409, miR-660, miR-942, miR-1290 | NA | Correlating to lung function parameters in children | Blood | 33128813 | Review |
| Childhood | miR-16, miR-30d, miR-296 | NA | Correlating to bronchial hyper-responsiveness | Blood | 33128813 | Review |
| Childhood | miR-146a, miR-206, miR-720 | NA | Potential asthma prediction markers | Blood | 33128813 | Review |
| Childhood | miR-223, miR-513a, miR-625 |
CBL, PPARGC1B, ESR1 |
Dust mite allergic asthma associated | Blood | 33128813 | Review |
| Childhood | miR-15a | VEGF | Low levels in CD4+ T cells in pediatric asthma | NA | 33128813 | Review |
| Childhood | miR-21 | IL-12p35 | Predicts therapeutic response to ICS in asthma | NA | 32777705 | Review |
| Childhood | miR-146a | EGFR | Up-regulation of miR‑146a inhibits proliferation and promotes apoptosis of ASMCs in asthma | NA | 32777705 | Review |
| Childhood | miR-221 | SIRT1 | Overexpression of miR-221 by targeting SIRT1 induces apoptosis and inhibits proliferation in bronchial epithelial BEAS2B cells | NA | 32777705 | Review |
| Childhood | miR-19a | PTEN, A20 |
Increased in airway T cells Reduction in smooth muscle cells leads to enhanced remodeling |
ASMCs | 33128813 | Review |
| Childhood | miR-485-5p | SPRED2 | Pediatric asthma | NA | 33488613 | Review |
| Childhood | miR-221 | SPRED, SIRT1 | Pediatric asthma | NA | 33488613 | Review |