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. 2022 Nov 25;49(4):248–258. doi: 10.5653/cerm.2022.05358

Figure 4.

Figure 4.

In vivo animal experiments. The histogram shows pregnancy rates. (A) Implantation sites on day 7.5 post-coitum in the different groups. In the transfected peripheral blood mononuclear cells (PBMCs) with recombinant vector (human chorionic gonadotropin [HCG]-producing PBMCs), the pregnancy rate and the number of implantation sites were significantly higher than in the other groups (analysis of variance, Tukey test). The number of pregnant mice out of the tested mice is shown, for example (8/9) means that out of 9 mice tested, 8 mice became pregnant. Values are presented as mean±standard deviation. (B-F) Examples of implantation sites in the uteri of studied pregnant mice in each group on day 7.5 post-coitum: (B) control, (C) embryo implantation dysfunction (EID), (D) EID+PBMCs, (E) EID+HCG, (F) EID+PBMC+HCG (HCG-producing PBMCs) groups. Control group, 16 implanted embryos; EID group, 3 implanted embryos; EID+HCG group, 6 implanted embryos; EID+PBMC group, 9 implanted embryos and EID with HCG-producing PBMC group, 12 implanted embryos.