Table 1.
Clinical characteristics of the patients from the study groups.
| Parameter | LMS patients Median (IQR) | BBS patients Median (IQR) | Obese patients Median (IQR) | Controls Median (IQR) |
|---|---|---|---|---|
| Age (years) | 18.9 (15.8, 22.9) | 10.7 (7.2, 16.3) | 14.6 (10.9, 17.1) | 16.0 (10.3, 17.9) |
| BMI (kg/m2) | 30.5 (27.4, 34.9) | 29.9 (25.9, 30.6) | 31.4 (29.0, 34.2) | 20.3 (16.9, 21.5) |
| BMI SDS | 4.2 (3.2, 4.7) | 3.7 (3.4, 4.2) | 4.1 (3.4, 4.6) | 0.1 (-0.3, 0.5) |
| Total cholesterol (mg/dL) |
174.0 (168.0, 193.0) | 171.0 (162.0, 219.5) | N/A | N/A |
| HDL-cholesterol (mg/dL) |
38.0 (29.5, 44.0) | 43.0 (38.0, 47.5) | N/A | N/A |
| LDL-cholesterol (mg/dL) |
121.0 (102.0, 140.5) | 168.0 (116.5, 173.5) | N/A | N/A |
| Triglycerides (mg/dL) |
139.0 (104.5, 309.0) | 157.0 (122.0, 177.8) | N/A | N/A |
| Creatinine (mg/dL) |
0.87 (0.76, 0.95) | 0.83 (0.78, 0.95) | N/A | N/A |
| Cystatin C (mg/dL) |
0.90 (0.83, 1.11) | 1.20 (0.82, 1.44) | N/A | N/A |
| Glucose (mg/dL) |
88.5 (7.0, 107.8) | 80.0 (71.0, 85.0) | N/A | N/A |
| Insulin (IU/l) |
27.0 (14.3, 33.4) | 7.5 (5.1, 10.3) | N/A | N/A |
| HOMA-IR | 5.9 (3.2, 9.1) | 1.6 (1.3, 2.0) | N/A | N/A |
| Hba1c (%) | 5.7 (5.6, 6.9) | 5.3 (5.3, 5.9) | N/A | N/A |
| C-peptide (ng/mL) | 6.2 (3.1, 7.7) | 1.9 (1.2, 2.0) | N/A | N/A |
Continuous data are presented as medians with values of the lower and upper quartile (IQR). ALMS, Alström syndrome; BBS, Bardet-Biedl syndrome; BMI, body mass index; HOMA-IR, homeostatic model of insulin resistance assessment; N/A, not available.