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Metabolic process of propofol in vivo. Propofol is rapidly metabolized into inactive compounds in the liver through the hydroxylation of cytochrome P450 (CYP2B6 and CYP2C9) isomers and the UDP-glucuronosyhransferase (UGT) pathway and excreted by the kidney. Less than 1% of propofol is excreted in urine and 2% in feces.
